The use of bisphosphonates to modulate bone remodeling is a widely accepted therapy. Their use is recommended also in dentistry in a wide variety of pathologies and treatments. For that, we performed a systematic review of the literature according to PRISMA statement. Aim of the present work is to evaluate if bisphosphonates locally administrated could improve primary stability od dental implants. As this therapy seems to enhance implant stability and have no drug related complications, there are a limited number of paper in literature to affirm that this could be an established therapy. For that reason, further studies are needed to establish if this could be a real guideline in implant insertion and management.