Peri-implant phenotypes is essential for long-term success because a thick biotype can lead to a better resistance against bacterial and mechanical damages. Plastic surgery of the peri-implant site is usually performed in order to gain a greater keratinized mucosa width. The purpose of this study was to evaluate the knowledge in literature about leucocytes platelet-rich fibrin (L-PRF) as an autologous solution to change peri-implant width. A case of L-PRF membranes around dental implants is also reported. The systematic review showed a lack of longitudinal long-term studies and a heterogeneity of protocol to produce L-PRF. At the best of our knowledge, L-PRF could represent a suitable soft tissue substitute to increase keratinized mucosa surrounding dental implants.