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Oral Implantology

HPV RELATED HEAD AND NECK CARCINOMA: A SHORT LITERATURE REVIEW ON TREATMENTS

Review, 72 - 76
doi: 10.11138/orl/2018.11.1.072
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Abstract
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Human papillomavirus (HPV) is responsible for a growing subset of oropharyngeal squamous cell carcinomas (OPSCCs) in the United States and abroad. At the time of the primary diagnosis, HPV-positive tumor status is associated with improved response to chemo-radiation, progression-free survival, and overall survival. Patients with HPV-related cancer look very different than the prototypic patient with tobacco-related SCC of the oral cavity. They tend to be white males that are younger, of higher socioeconomic status, and more highly educated. Moreover, they are often non-smokers who do not abuse alcohol. HPV-related SCC has a strong predilection for the oropharynx, particularly the lingual and palatine tonsils.
HPV-16 genotype is the most common genotype, accounting for up to 92% of HPV-positive oropharyngeal squamous cell carcinomas. The need for routine HPV testing of oropharyngeal carcinomas is urgent and compelling. First, HPV status is a powerful indicator of patient prognosis. HPV positivity correlates with a lower risk of tumor progression and death, reflecting in part an enhanced sensitivity to ionizing radiation with or without chemotherapy. In our understanding, HPV status, which is easily acquired with routine investigations, should be included in the standard operational procedures for the diagnosis and treatment of head and neck cancer patients.

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